According to the CDC, as of 2023, 38.4 million people — 11% of the population — have diabetes; 97.6 million aged 18 and above are prediabetic. I am interested in studying the effect of methylglyoxal (MG) on PC12 neuronal and BV2 macrophage cell lines. High level of MG have been detected in diabetic patients through glycolysis, and it is has been linked to the cytotoxic effects in diabetes. I am also interested in studying the oxidative stressors related to high levels of MG and the protective role of antioxidants such as the internal antioxidant glutathione, vitamin C and turmeric in protecting cells in diabetes.

Keywords: hyperglycemia, Methylglyoxal, oxidative stressors, glutathione