Fibroblast growth factor (FGF) signal transduction
Cell migration guidance mechanisms in the nematode C. elegans
Ph.D., University of California, Berkeley (Biochemistry)
B.S., Yale University (Molecular Biophysics and Biochemistry), summa cum laude
Thomas, J.H., Stern, M.J. and Horvitz, H.R. (1990) "Cell interactions coordinate the development of the C. elegans egg-laying system." Cell 62:1041-1052. PMID: 1821851
Clark, S.G., Stern, M.J., and Horvitz, H.R. (1992) "C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains." Nature 356:340-344. PMID: 1372395
Mihaylova, V.T., Borland, C.Z., Manjarrez, L., Stern, M.J., and Sun, H. (1999) "The PTEN tumor suppressor homolog in C. elegans regulates longevity and dauer formation in an insulin-receptor like signaling pathway." Proc. Natl. Acad. Sci. U.S.A. 96:7427-7432. PMID: 10377431
Kam, N., Kugler, H., Marelly, R., Appleby, L., Fisher J, Pnueli, A., Harel, D., Stern, M.J., Hubbard, E.J. (2008). “A scenario-based approach to modeling development: a prototype model of C. elegans vulval fate specification.” Dev. Biol. 323:1-5. PMID: 18706404
Lo, T.-W., Bennett, D.C., Goodman, S.J., and Stern, M.J. (2010). “Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2.” Genetics 185:537-547. PMID: 20308281
My research interests involve biological and computational approaches to understanding developmental biology, which is the process by which complex, multicellular animals develop from single-cell fertilized eggs. My biological interests have focused on understanding how cells within multicellular animals “talk” to each other to coordinate the requisite developmental processes that generate and maintain the normal structures and functions of complex, multicellular animals. The regulatory mechanisms that coordinate these processes are often the targets of mutations that cause a wide range of pathologies, including cancer.
My specific areas of focus have concentrated on analyzing the cell-to-cell signaling mechanisms that guide migrating cells to their proper targets and that mediate fibroblast growth factor (FGF) signal transduction. My laboratory uses molecular-genetic approaches to study the cell migrations of the sex myoblasts and FGF signaling in the nematode Caenorhabditis elegans.
Wormbase profile: Michael Stern
Northeastern Illinois University
5500 North St. Louis Avenue
Chicago, IL 60625